Pandemic preparedness emerging pathogens, virus discovery, surveillance, public health.Ĭopyright © 2022 The Author(s). A novel element of the APDC is the capacity for early development and rapid deployment of scalable, quality diagnostics targeting newly identified pathogens of pandemic potential. As of January 2022, the APDC network has partners on 5 continents including academic institutions, governmental, and nongovernmental organizations. The APDC is a global multisector scientific and public health partnership whose primary objective is the early detection and mitigation of infectious disease threats of pandemic potential. As a natural extension of Abbott's work in diagnostics, virus discovery, and virus surveillance, the Abbott Pandemic Defense Coalition (APDC) was launched in early 2021. The rapid global spread of severe SARS-CoV-2 in 2020 highlighted the critical role of diagnostics in understanding the epidemiology of the virus early in the pandemic. 1 Global Scientific Affairs, Abbott Diagnostics, Abbott Park, IL 60064, USA.

17 Mahidol University, Bangkok, Thailand.ĭetection and epidemiologic characterization of infectious disease outbreaks are key for early identification and response to potential pandemic threats.

16 Centre for Epidemic Response and Innovation, Stellenbosch University, Stellenbosch, South Africa.

15 Johns Hopkins University School of Medicine, USA & YRG CARE, Chennai, India.

14 Foundation Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.13 Uganda Virus Research Institute, Entebbe, Uganda.12 Institute for Health Research, Epidemiologic Surveillance and Training (IRESSEF), Dakar, Senegal.11 University of Zimbabwe, Harare, Zimbabwe.10 University of the West Indies, Kingston, Jamaica.9 Quisqueya University, Port-au-Prince, Haiti.

8 Colombia Wisconsin One Health, University of Wisconsin & National University of Colombia, Medellin, Colombia.7 University of Sao Paulo, Sao Paulo, Brazil.6 National Center for Disease Control, Tbilisi, Georgia.5 Rush University Medical Center, Chicago, IL, USA.4 Abbott Diagnostics (deceased), Abbott Park, IL, USA. STANDING STONE, LLC is an Active company incorporated on Septemwith the registered number M20000008133.Electronic address: 3 Abbott Diagnostics, Abbott Park, IL, USA. Diagnostic testing is a compass, providing information that helps in. Electronic address: 2 Abbott Diagnostics, Abbott Park, IL, USA. Our 115,000 colleagues serve people in more than 160 countries. 1 Abbott Diagnostics, Abbott Park, IL, USA.HBV genotypes HBsAg HBsAg mutants Immunoassay Nucleic acid test (NAT).Ĭopyright © 2018 Elsevier B.V. The assay has superior HBsAg mutant and genotype detection and specificity, all of which are important for the diagnosis and management of HBV infection. The improvement in sensitivity did not diminish assay specificity, attaining 100% (95% CI, 99.97-100%) on 10,633 blood donors.Īn Abbott ARCHITECT ® HBsAg assay with clinical performance approaching that of mini-pool NAT (approximately 100 copies/ml was developed. Further, the assay detected 7 of 12 HBV DNA positive/HBsAg negative samples, and detected all evaluated mutants and genotypes with higher sensitivity than the comparator assays. Abbott Laboratories is committed to helping people live better lives through the power. the ARCHITECT ® Qual I (144), Qual II (160) and PRISM ® (148) HBsAg assays. 100 Abbott Park Road Abbott Park, IL 60064. The enhanced sensitivity was also demonstrated with 27 HBV seroconversion panels, detecting more panel members (191 of 364) vs. Executive Vice President - Rapid and Molecular Diagnostics, Senior Management. The analytical sensitivity of the improved prototype assay is 5.2 mIU/ml, which is 3.86- to 14.54-fold more sensitive than comparator assays based on the WHO International Reference Standard. Abbott is headquartered in Abbott Park, Illinois, the US. Improvements in HBsAg assay sensitivity approaching the performance of nucleic acid testing (NAT) are essential to further reduce the detection window for acute HBV infection in regions where NAT is not widely available.Īn improved HBsAg assay on the fully-automated Abbott ARCHITECT ® platform was developed to improve sensitivity, mutant and genotype detection. Critical to the identification of HBV infection and the prevention of transfusion transmitted disease is the sensitive and accurate detection of Hepatitis B virus surface antigen (HBsAg).

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